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Merck等公司选拔新技术商量抗癌药,肉瘤相关

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Merck等公司选拔新技术商量抗癌药,肉瘤相关

摘要: Merck、Roche、Sanofi等厂家的研究人口选取新技能研究开发医治骨良性肿瘤药物,以期得到新的突破。举个例子Sanofi公司正在研产生机勃勃种针对p53蛋白的药品来医疗脂肪肉瘤。Merck等集团将精力聚集在查找p53蛋白的压制物来搜寻新的药品。...

入眼词:Sanofi,Merck,骨良性肉瘤新靶标

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二〇一三年110月十二日讯 /生物谷BIOON/ --Merck、Roche、Sanofi等公司的商讨人士采纳新技巧研究开发医疗肉瘤药物,以期获取新的突破。譬喻Sanofi集团正在研究开发蓬蓬勃勃种针对p53蛋白的药物来治病脂肪肉瘤。

Merck、Roche、Sanofi等营业所的钻研人口接收新本领研究开发治疗骨瘤药物,以期得到新的突破。譬喻Sanofi公司正在研究开发大器晚成种针对p53蛋白的药物来治病脂肪骨瘤。

早年肉瘤的钻研是本着产生癌细胞的器官举行钻探,未来斟酌人口希望通过搜寻癌细胞上的分子靶标来研究开发药物。Merck等商场将精力集中在追寻p53蛋白的制止物来寻找新的药品。P53蛋白是风姿洒脱种能够遏抑细胞凋亡的蛋清,在毒瘤中表明量超高。

既往骨良性肉瘤的研商是针对产生癌细胞的五藏六府举办研究,将来探究人士期望经过搜寻癌细胞上的积极分子靶标来研究开发药物。Merck等营业所将精力聚集在搜求p53蛋白的遏制物来索求新的药物。P53蛋白是意气风发种能够遏制细胞凋亡的蛋白,在毒瘤中表达量非常高。

美利哥癌症学会的Dr. Otis WebbBrawley以为这种方法是肿瘤药物研究开发的前途。(生物谷Bioon.com)

United States骨良性癌症学会的Dr.OtisWebbBrawley以为这种方式是气瘤药物研发的前景。

详见意大利语报导:

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Cancer researchers have been rethinking the way new drugs are developed as investigations of new medicines focus more on molecular targets than on the organs where tumors originate. And this evolution in clinical development has crossed paths with the race to advance drugs that restore function of a protein to send cancer cells to their grave.

At the intersection are pharma companies such as Merck , Roche and Sanofi and smaller players such as Cellceutix seeking breakthroughs.

They have probed the role of the p53 protein in the death of cells with damaged DNA, and how cancer cells have found a variety of ways to stymie p53 function to stay alive and multiply. Yet pharma outfits have long hunted for drugs to revive the activity of the protein without much to show for their labors in human cancers.

Over the weekend The New York Times highlighted the progress of the three drug giants in the race to advance drugs that impact p53, which is incapacitated in a variety of common and rare cancers. Sanofi is advancing one of its compounds in a trial focused on patients with a rare fat-cell cancer known as liposarcoma, but the ubiquity of p53 inactivation across tumor types opens the door to testing individual drugs against cancers in many different organs at the same time.

"This is a taste of the future in cancer drug development," said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society, in the Times article. "I expect the organ from which the cancer came from will be less important in the future and the molecular target more important."

Of course, behind many hot targets in cancer research are compelling stories of wiping out tumors, with the most compelling successes often found in mice, unfortunately. Cancer cells conspire in a variety of ways, including attachment of double minute 2 proteins to p53, to silence the kill switch.

Roche has already fallen short with compounds known as Nutlins (named after its Nutley, NJ, lab) that were designed to free p53 from the clutches of the double-minute protein. Tantalizing discoveries in the lab aren't often easy to translate into useful drugs. But Roche and others haven't given up on this target.

(主要编辑:jie.jiang卡塔尔(قطر‎

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